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  1. 国外雑誌掲載論文
  2. 西村 直道

Colonic Hydrogen Generated from Fructan Diffuses into the Abdominal Cavity and Reduces Adipose mRNA Abundance of Cytokines in Rats.

https://nayoro.repo.nii.ac.jp/records/1076
https://nayoro.repo.nii.ac.jp/records/1076
415ae37f-cbb5-4061-b810-0939601c267c
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-11-22
タイトル
タイトル Colonic Hydrogen Generated from Fructan Diffuses into the Abdominal Cavity and Reduces Adipose mRNA Abundance of Cytokines in Rats.
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Naomichi, Nishimura

× Naomichi, Nishimura

WEKO 362
CiNii ID 9000018689760
e-Rad 10341679

en Naomichi, Nishimura

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Hiroki, Tanabe

× Hiroki, Tanabe

WEKO 363
CiNii ID 9000018689761
e-Rad 60573920

en Hiroki, Tanabe

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Adachi, Misato

× Adachi, Misato

WEKO 1547
CiNii ID 1380298337576268674

en Adachi, Misato

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Tatsuro, Yamamoto

× Tatsuro, Yamamoto

WEKO 364
CiNii ID 9000018689762
e-Rad 90379389

en Tatsuro, Yamamoto

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Fukushima, Michihiro

× Fukushima, Michihiro

WEKO 1549
CiNii ID 1000020231558
e-Rad 20231558

en Fukushima, Michihiro

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抄録
内容記述タイプ Abstract
内容記述 Hydrogen (H2) protects against inflammation-induced oxidative stress. Nondigestible saccharides (NDSs) enhance colonic H2 production. We examined whether colonic H2 transfers to tissues in the abdominal cavity and whether it affects expression of proinflammatory cytokines. In Expts. 1 and 2, rats were fed diets containing fructooligosaccharides [FOSs; 25 (Expt. 1) and 50 g/kg (Expts. 1 and 2)] for 7 and 14 d, respectively. The no-FOS diet was used as the control diet. At the end of the experiment, H2 excretion and the portal H2 concentration were significantly greater in the FOS group than in the control group. In the FOS group, the arterial H2 concentration was no more than 1.5% of the portal H2 concentration (P = 0.03). The H2 concentration in abdominal cavity tissues, especially adipose tissue, in the FOS group was 5.6- to 43-fold of that in the control group (P < 0.05). The H2 content in the abdominal cavity in the FOS group was 11-fold of that in the control group (P < 0.05). In Expt. 3, rats were fed a high-fat diet containing FOS and inulin (50 g/kg) for 28 d. The area under the curve for H2 excretion between 0 and 28 d and portal and adipose H2 concentrations were significantly higher in the FOS and inulin groups than in the high-fat control group. Adipose mRNA abundance of nuclear factor kappa-light-chain-enhancer of activated B cells 1 was lower in the FOS group than in the control group (P = 0.02) and those of interleukin-6 and chemokine (C-C motif) ligand 2 tended to be lower (P < 0.11). Colonic H2 generated from NDS diffuses to the abdominal cavity before transferring to abdominal tissues. Reduced cytokine expression by FOS feeding might be dependent on increased colonic H2. Colonic H2 may have important implications in the suppressive effect on metabolic syndrome via oxidative stress.
言語 en
内容記述
内容記述タイプ Other
内容記述 Hydrogen (H2) protects against inflammation-induced oxidative stress. Nondigestible saccharides (NDSs) enhance colonic H2 production. We examined whether colonic H2 transfers to tissues in the abdominal cavity and whether it affects expression of proinflammatory cytokines. In Expts. 1 and 2, rats were fed diets containing fructooligosaccharides [FOSs; 25 (Expt. 1) and 50 g/kg (Expts. 1 and 2)] for 7 and 14 d, respectively. The no-FOS diet was used as the control diet. At the end of the experiment, H2 excretion and the portal H2 concentration were significantly greater in the FOS group than in the control group. In the FOS group, the arterial H2 concentration was no more than 1.5% of the portal H2 concentration (P = 0.03). The H2 concentration in abdominal cavity tissues, especially adipose tissue, in the FOS group was 5.6- to 43-fold of that in the control group (P < 0.05). The H2 content in the abdominal cavity in the FOS group was 11-fold of that in the control group (P < 0.05). In Expt. 3, rats were fed a high-fat diet containing FOS and inulin (50 g/kg) for 28 d. The area under the curve for H2 excretion between 0 and 28 d and portal and adipose H2 concentrations were significantly higher in the FOS and inulin groups than in the high-fat control group. Adipose mRNA abundance of nuclear factor kappa-light-chain-enhancer of activated B cells 1 was lower in the FOS group than in the control group (P = 0.02) and those of interleukin-6 and chemokine (C-C motif) ligand 2 tended to be lower (P < 0.11). Colonic H2 generated from NDS diffuses to the abdominal cavity before transferring to abdominal tissues. Reduced cytokine expression by FOS feeding might be dependent on increased colonic H2. Colonic H2 may have important implications in the suppressive effect on metabolic syndrome via oxidative stress.
言語 en
書誌情報 en : The Journal of nutrition

巻 143, 号 12, p. 1943-1949, 発行日 2013-10-01
出版者
出版者 American Society of Nutritional
言語 en
ISSN
収録物識別子タイプ EISSN
収録物識別子 1541-6100
PubMed番号
識別子タイプ PMID
関連識別子 24132574
DOI
識別子タイプ DOI
関連識別子 10.3945/jn.113.183004
関連サイト
識別子タイプ URI
関連識別子 http://jn.nutrition.org/content/143/12/1943.abstract
言語 en
関連名称 The Journal of nutrition
フォーマット
内容記述タイプ Other
内容記述 学内のみ閲覧可
言語 en
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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